При раке случился инсульт

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EPICRISIS
Patient case description No. 10-27979
Issued day: 2010-November-10
State institution
Vilnius University Hospital
Santariskes clinics
VLADIMIR MAGIT
Date of birth: 1947-12-21
Home address: Geroves Str. 19-11, Vilnius

Abdominal surgery center
The first abdominal surgery department
Date of hospitalization: 2010-November-04 12:25:00
Date of leaving: 2010-November-10
Diagnosis at the moment of hospitalization: STOMACH NEOPLASM

Clinical Diagnosis:
Ventricular adenocarcinoma T3N2M1. Hepatic metastases. Carcinomatosis. Chronic pulmonary embolism. Bilateral thrombosis of lower calf veins.

Patient complaints and disease history: general malaise, constant pain in the epigastrium, loss in body weight.
Symptoms appeared three weeks ago. After performing Esophagogastroscopy (EGD) the stomach neoplasm is diagnosed, the biopsy results showed the adenocarcinoma. The computed tomography (CT) showed metastases in the liver and omentum. The purpose of hospitalization was to perform the liver biopsy for verification of the extent of the disease.

Patient status at presentation:
The general condition is satisfactory. Blood pressure (BP) 130/80 mg/mm H, Pulse rate (P): 74/min. Lungs: breathing is vesicular without crackles. Palpated abdomen is soft, tender in the epigastrium, without signs of peritoneal irritation.

Conducted diagnostic and laboratory tests:
Laboratory tests
Blood test (2010-November-04): WBC (*10e9/l)-12.07, NEU (%) – 72.2, LYM (%) -16.5, MON (%) 9.9 EOS (%) -0.8, Lazdeliniai (%)3.6, Segmintuoti (%) – 83.7, BAS (%) – 0.2, Monocytes (%) – 3.6, IG (%) – 0.4, NRBC (%) – 0.0, Basophils (%) -0.9, NEU (*10e9/l) – 8.72, LYM (*10e9/l) – 1.99, MON (*10e9/l) 1.19, EOS (*10e9/l) -01, BAS (*10e9/l) -0.02, IG (*10e9/l) – 0.05, NRCB (*10e9/l) -0.00, RCB (*10e9/l) – 4.12, Hgb (g/l) – 104, Hct (l/l) -0.329, MCV (fl) – 79.9, MCH (pg) – 25.5, POLY polychromatophilia – 0, HYPO hypochromia – 1, MCHC (g/l) – 316, RDW-SD (fl) – 41.1, ANISO anisocytosis – 1, MICRO microcytosis – 0, P-LCR (%) – 26.3, Plt ([10e9/l) – 239, MACRO macrocytosis – 0, POIKILO pokilocytosis – 1, MPV (fl) – 10.3, Pct (%) -0.25, PDW (%) – 11.5, ENG according Westergren method (mm/h) – 54, Toxic grain – 1.

Coagulation tests (2010-November-04 and 2010-November-05):

Blood test (2010-November-05):

OTHER DIAGNOSTIC TESTS:
Esophago-gastro-duodenoscopy and biopsy (2010-November-04):
Endoscope easily was introduced into esophagus. Lumen of esophagus is unobstructed, esophagus mucosa is unchanged. Entrance into cardia is tight. There some bilious fluid and mucus. There is approx. 6 cm neoplastic ulceration with surrounded tissue infiltration in the stomach angular region, the greater curvature. The biopsy was taken. Pylorus is of normal shape, undeformed. Duodenal bulb is of normal shape, mucosa is unchanged. Lumen of descending part of duodenum as well as mucosa is unchanged.
Conclusion: Ventricular neoplasm.

X-RAY OF THE LUNGS (2010-November-04):
There are no visible foci or dim-outs in x-ray picture. Lung branches are unexpanded, structured. The fluid is not visible in the pleural cavity. Diaphragm is partly relaxed from the right side. Heart shadow is unexpanded. Aorta is normal.
Conclusion: Changes in the lungs are not seen.

COMPUTED TOMOGRAPHY OF ABDOMEN REGION (2010-November-04):
The knarred overflow defects – thrombi, are seen in the lung arteries of the scanned parts of lungs. Stomach is outstretched and contrasted by water. In the Antrum part there is a tumorous infiltration  5-6 cm long, it encompasses angular region up to 12 mm and along the stomach back wall and lesser curvature, and it is pervasive on the upper-middle third of the stomach body. Perigastric fat in front of the tumor is infiltrated, stomach lumen is constricted. There are a lot of enlarged lymph nodes: supra-, infrapyloric as well as along the lesser curvature, a.v. gastrica sin. and hepatic ligament.
In the greater omentum from the left there are focuses of carcinomatosis: 1 cm and 7 mm.
Liver is not enlarged; there are multiple hypovascular foci in the both lobes – S2 – up to 2.7 cm, S4 – 1.7 cm, in the right lobe – up to 1.3 cm.
Intrahepatic bile ducts are enlarged. Bile cyst is the normal size, the walls is not thickened. V. portae and its branches are without thrombi. Itrahepatic part of v. cava inf. is without thrombi, hepatic veins are contrasted. Exstrahepatic bile ducts are not expanded, intrapancreatic part of the common bile ducts – 3 mm. Pancreas is not enlarged, the head- 20 mm, the body – 15 m, the tail – 18 mm. There are no foci in the parenchyma, the duct is not extended. Spleen – 110 mm, no foci are seen in the parenchyma. V. lienalis -8 mm, without thrombi. In the right adrenal gland – 2 cm, in the left one – up to 1.2 cm low density focuses (native – 9HV), the left adrenal gland – diffusely enlarged. Kidney is of normal localization, the size and formation s are not seen. Renal collectorial system is not extended.
Conclusion: Stomach tumor (adenoCa type) ctT3N2M1, multiple metastases in liver, metastatic lymphadenopathy, carcinomatosis in omentum. Adrenal adenomas, signs of the pulmonary artery embolism.

12 DERIVATIONS’ ECG (PSGA) (2010-November-05):

Conclusion: Sinus rhythm. In the range of age.

ULTRASOUND INVESTIGATION OF HEART (2010-November-05):
Conclusion: The systolic function of Left ventricle is good. O-I*. The dilatation of the Right ventricle. There are no sings of Pulmonary arterial hypertension (PLAH). II*MVN. I* dilatation of the left atrium. I* left atrium – diastolic functional disorder.

DUPLEX SCANNING OF THE LOWER LIMB VEINS:
Conclusion: In the right leg there is chronic thrombosis of the calf profound veins (recanalisation is insignificant). In the left leg there is likely subacute profound vein thrombosis in thigh and calf.

Blood test (2010-November-09):

Coagulation test (2010 -November -10)

Treatment:
2010 November 05 – the S2 MTS liver biopsy. No complications were observed. There was a cardiologist consultation regarding thromboemlia. Prescribed treatment: LMWH 5000 vv i/p 2 x day. Afterwards it was recommended to continue Warfarin 5 mg orally QD observing INR (it should be in the range of 2.8-3). Upon developing tachycardia (80-90/min) it is recommended to take diltiazemum -120 mg 2 x day.
After specialists advising board (oncologist, surgeon and radiologist) decision it is indicated the course of chemotherapy, after which the patient should be investigated repeatedly to decide about surgery.
Vascular surgeon consultation: the compression socks, Sol. Fragmin 5000 vv i/p 2 x 2 weeks. After 2 months it is recommended to visit vascular surgeon and repeat duplex scan of at the day of issue from hospital:
The condition is satisfactory. HD is stable. Abdomen is soft, non tender.
Recommendations;
To receive histological results
Consultation for the chemotherapy
Sol. Fragmin 5000 vv i/p 2 x 2 weeks, then Sol. Fragmin 5000 vv i/p 1 x day + tab. Warfarin 5 mg orally watching INR (in the range 2.8-3)
Control:
After chemotherapy: the consultation of the prof. K. Strupas regarding the surgery
After 2 months –consultation of vascular surgeon and DUPLEX scan of both legs.

Physician : Jonas Jurgaitis
Department head: Poškus Eligijus

Добрый день.
Такой вопрос. Может быть кто-то сталкивался с такой ситуацией. У свекрови после рака груди, после того как отрезали ее, пошли метастазы в кости, в течение 3 лет метастазы больше всего атаковали ноги, коленки. Она лежит не встаёт. Из-за боли. 2 дня назад, у неё был микроинсульт (по записям врачей). Сейчас она в больнице под капельницами. Вся левая половина тела парализована. Говорит еле-еле. Иногда непонятно что. Смотрит тупо в одну точку. Никакого интереса к происходящему.ни эмоций. Ничего. Кости болят, сказать об этом не может, только одной рукой показывает, чтобы ноги ей переместили. Так вот, связано ли это с метастазами или микро инсульт это отдельно как-то было? Однозначно, что мозг у неё поражён и она иногда бредит. Возможно ли восстановление в такой ситуации хотя бы до того состояния, когда она была в нормальном сознании. Врачи ничего не говорят и ничего не знают. Дети вокруг неё 2 день не отходят ни днём ни ночью. Может кто-то сталкивался, долго ли ей осталось?. И основной вопрос, связано ли это с метастазами??? Могут ли метастазы так поразить мозг? Иди инсульт это все таки отдельно как-то от всего? Может быть из-за количества лекарств не выдержали сосуды